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Global Dravet Syndrome Market: Industry Analysis & Outlook (2019-2023)
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Date: 01, February 2019 | Pages: 62
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Dravet syndrome, formerly known as severe myoclonic epilepsy of infancy (SMEI), is a severe kind of epilepsy which causes seizures. High fever is usually a trigger for these seizures. It is a rare disorder that affects an estimated 1 in every 20,000–40,000 births. It usually develops in the six month of age. It is caused by loss-of-function mutations in one copy of the SCN1A gene. Patients with Dravet syndrome are not able to produce sufficient levels of functional Nav1.1 sodium channel, preventing inhibitory neurons from firing properly.

 

The disorder is considered orphan indication. And there are very limited treatment options available in the market. However, several therapeutics for Dravet syndrome are in pipeline. The drugs in development are getting orphan drug designation by FDA and EMA. The Dravet syndrome market in Europe and the U.S. is likely to exhibit significant growth in the next five years due to increasing research and development activities conducted by several companies. Several companies are making alliances for developing therapeutics for Dravet syndrome. Currently, the U.S and Europe are holding the potential growth for Dravet Syndrome market due to increasing R&D into new drug development for Dravet syndrome and approval for these drugs in these regions.

 

Key players of the market include Zogenix, Zynerba, GW Pharmaceuticals, and OPKO. Currently, only GW Pharmaceuticals’ Epidiolex is commercially available. Other players are currently developing their drugs or seeking for commercial approval by FDA and EMA. Zogenix’s ZX008 is expected to penetrate market in 2019 and create competition for GW Pharmaceuticals. Currently, the market is dominated by generic drugs.
 

 

1. Overview

 

1.1 Dravet Syndrome

 

2. Global Dravet Syndrome Drug Market

 

2.1 ZX008 Sales Value Forecast
2.2 Epidiolex Sales Value Forecast

 

3. Regional Dravet Syndrome Drug Market

 

3.1 The U.S.
3.1.1 The U.S. Dravet Syndrome Patient Volume Forecast
3.1.2 ZX008 Sales Value Forecast in the U.S. Dravet Syndrome Market
3.1.3 Treated Dravet Syndrome Patients with ZX008 in the U.S. Forecast
3.1.4 ZX008 Penetration Forecast in the U.S. Dravet Syndrome Market
3.1.5 Epidiolex Sales Value Forecast in the U.S. Dravet Syndrome Market
3.1.6 Treated Dravet Syndrome Patients with Epidiolex in the U.S. Forecast
3.1.7 Epidiolex Penetration Forecast in the U.S. Dravet Syndrome Market

 

3.2 Europe
3.2.1 Europe Dravet Syndrome Patient Volume Forecast
3.2.2 ZX008 Sales Value Forecast in Europe Dravet Syndrome Market
3.2.3 Treated Dravet Syndrome Patients with ZX008 in Europe Forecast
3.2.4 ZX008 Penetration Forecast in Europe Dravet Syndrome Market
3.2.5 Epidiolex Sales Value Forecast in Europe Dravet Syndrome Market
3.2.6 Treated Dravet Syndrome Patients with Epidiolex in Europe Forecast
3.2.7 Epidiolex Penetration Forecast in Europe Dravet Syndrome Market

 

4. Market Dynamics

 

4.1 Growth Drivers
4.1.1 Attractive Orphan Drug Policies
4.1.2 Rising Healthcare Expenditure
4.1.3 Accelerating Economic Growth
4.1.4 Rising Strategic Alliances

 

4.2 Key Trends
4.2.1 Development of New Therapeutics
4.2.2 Approval of Cannabidiol Drugs for Dravet Syndrome

 

4.3 Challenges
4.3.1 Regulatory Challenges
4.3.2 Associated Risks
4.3.3 Insufficient Disease Information and Research Participants
4.3.4 Rising Competition from Generic Industry

 

5. Competition

 

5.1 Global Market
5.1.1 Revenue Comparison of Key Players
5.1.2 Market Cap Comparison of Key Players
5.1.3 Comparison of Epidiolex and ZX008

 

6. Company Profiles

 

6.1 Zogenix
6.1.1 Business Overview
6.1.2 Financial Overview
6.1.3 Business Strategies

 

6.2 Zynerba
6.2.1 Business Overview
6.2.2 Financial Overview
6.2.3 Business Strategies

 

6.3 OPKO
6.3.1 Business Overview
6.3.2 Financial Overview
6.3.3 Business Strategies

 

6.4 GW Pharmaceuticals
6.4.1 Business Overview
6.4.2 Financial Overview
6.4.3 Business Strategies

 

List of Charts

 

Global ZX008 Sales Value Forecast (2019-2023)
Global Epidiolex Sales Value Forecast (2019-2023)
The U.S. Dravet Syndrome Patient Volume Forecast (2018-2023)
ZX008 Sales Value Forecast in the U.S. Dravet Syndrome Market (2019-2023)
Treated Dravet Syndrome Patients with ZX008 in the U.S. Forecast (2019-2023)
ZX008 Penetration Forecast in the U.S. Dravet Market (2019-2023)
Epidiolex Sales Value Forecast in the U.S. Dravet Syndrome Market (2019-2023)
Treated Dravet Syndrome Patients with Epidiolex in the U.S. Forecast (2019-2023)
Epidiolex Penetration Forecast in the U.S. Dravet Syndrome Market (2019-2023)
Europe Dravet Syndrome Patient Volume Forecast (2018-2023)
ZX008 Sales Value Forecast in Europe Dravet Syndrome Market (2020-2023)
Treated Dravet Syndrome Patients with ZX008 in Europe Forecast (2020-2023)
ZX008 Penetration Forecast in Europe Dravet Syndrome Market (2020-2023)
Epidiolex Sales Value Forecast in Europe Dravet Syndrome Market (2019-2023)
Treated Dravet Syndrome Patients with Epidiolex in Europe Forecast (2019-2023)
Epidiolex Penetration Forecast in Europe Dravet Syndrome Market (2019-2023)
Global Healthcare Expenditure Per Capita (2014-2018)
Global GDP Per Capita (2014-2018)
Revenue Comparison of Key Players (2017)
Market Cap Comparison of Key Players
Pivotal Phase Data of Epidiolex and ZX008
Zogenix Total Revenue and Net Loss/Income (2013-2017)
Zogenix R&D Expenditure (2015-2017)
Zynerba Revenue & Net Loss (2013-2017)
Zynerba R&D Expenditure (2015-2017)
OPKO Revenue by Segment (2017)
OPKO Revenue and Net Loss (2013-2017)
OPKO R&D Expenditure (2015-2017)
GW Pharmaceuticals Revenue by Segment (2017)
GW Pharmaceuticals Revenue and Loss of the year (2013-2017)

 

List of Tables

 

Orphan Drug Policies
Dravet Syndrome Therapeutics Pipeline
Zynerba Product Pipeline

 

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